How do I use a Ledger Nano hardware wallet?

I’m thinking of buying a Ledger Nano S. Is it easy to use? Any guide would be good.

Yes, it is extremely easy to use! Your seed is safely stored inside the device and you just plug it into your PC or MAC and connect it to a nano wallet that supports it.

Check out this video guide (and text guide) to get started.

As of writing, supporting sites are NanoVault or its clone MyNinjaVault
The recommended application is the NanoVault desktop version